Is it possible for somebody to achieve testosterone suppression through sublingual Estradiol tablets? I know that in theory you should be able to just take several tablets a day but I was wondering if anybody else had chosen this route?

  • AnonymousCoward@lemmy.blahaj.zoneOPEnglish
    3·
    2 months ago

    I just started HRT, Oral 2MG estradiol. I was just curious because I know that most of the sublingual meds are supposed to go directly into your blood stream and what heads to your liver should be minimal, as opposed to oral where the dose has to be high enough to pass through your liver.

    I think I’m willing to pop them like tic tacs if needed. Image

    • dandelion@lemmy.blahaj.zone
      3·
      2 months ago

      Sublingual might have better absorption than oral, but that isn’t saying much and you are still swallowing some of the dose. I still think the dose you would need to do monotherapy is more than is reasonable for oral or sublingual routes of administration.

      Also, it’s not just how many pills you would need to take to keep up your levels, but the exact timing. It also means all day you are constantly having sharp increases and decreases in your hormone levels. It’s impractical for lots of reasons.

      Injections are ideal for monotherapy, but if that’s not an option I would stick to more typical doses of sublingual estrogen and an anti-androgen (though the anti-androgens can have side effects). Patches and gel are better for absorption than oral (most of the estrogen is absorbed by the liver, little of your dose gets into the bloodstream - it’s really the worst route of administration), but they have their own logistical problems.

      I highly recommend reading this: https://transfemscience.org/articles/transfem-intro/