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Cake day: July 14th, 2024

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  • There’s a feature of some Long COVID cases (~50%) which is also the defining feature of an illness called ME/CFS which has been caused by various forms of viral infections throughout history. (It is thought that a lot of Long COVID cases are ME/CFS). Anyways this feature is, Post-Exertional Malaise, a worsening of the illness after exertion beyond a certain threshold, which can entail hundreds of symptoms and be permanent.

    This paper is a review of some of the biomedical studies looking at what could possibly cause this, and finds there is repeated data of Microvascular (blood vessels) and immunometabolic (metabolic markers relating to immune function) differences with healthy controls.

    The leading hypotheses are that this is caused by mitochondrial dysfunction which is mediated by a dysregulated immune system.

    Some of my colleagues were co-authors on this paper. I’ll forward the feedback that it is jargony.





  • Hey I have a MD with residency in Neurology. Then I did a PhD in Neuroimmunology with board certification.

    I’m currently doing a hectic mix of teaching two med courses, working on Long COVID research (biomarkers), and working in an understaffed long COVID (now post-viral disease) clinic.

    Nice to meet you.

    I mostly lurk on lemmy, but that’s because I haven’t found a place I’d like to consistently contribute yet. Maybe here?










  • Neurologist@mander.xyzOPtoPoems@reddthat.comPlague Poems
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    1 month ago

    If you’re healthy.

    Sucks to be disabled or immunocompromised or at risk in any other way…

    Also, it’s still killing at much higher rates than the flu.

    And I won’t even start getting into Long COVID, which I’m currently researching. But it is a major crisis. 2-4 million people unable to work in the US because of it.









  • unpopular opinion is not the same thing as academic literature lol makes sense.

    Though I found the points to be well thought it (if not clearly written in a rush).

    Also to be fair given the post, they could likely be a med student or something. Most people aren’t aware of the specific biological factors they listed nor some of the conditions, as OP used some medical terminology not often seen used by layman.



  • That’s only in some schools of thought of psychology.

    There are plenty of praticing psychologists and psychiatrists (some of my colleagues) who genuinely believe and publish research along the lines of “all mental illness are caused by thoughts and behaviours”. Research that in my opinion is heavily flawed, but still published and peer reviewed, so a lot of people in the field think this way.



  • As a neurologist, who has recently specialised in Long Covid. I’d say 95% of studies in the field are untrustworthy.

    As with any health condition where the biological factors are unknown, a group of psychiatrists and psychologists, the same that targeted autoimmune diseases before they were proven to be “real”, have flooded the field claiming patients are suffering from hysteria or psychological issues.

    None of their studies manage to prove anything whatsoever. They have published thousands of studies which go something along the line of: “People with long covid have more mental health issues, therefore, long covid is not real, but caused by hysteria”.

    This proves no correlation whatsoever though. Every single chronic illness / disability has higher rates of mental health issues, yeah turns out being poor and marginalised + loosing a lot of what you had in life + chronic pain is not good for your mental health. In fact studies have found that before the covid infection these people have the same rate of mental illness as the normal population.

    This is just one example, but legitimately > 90% of psychiatry / psychology studies I read in my field are extremely poorly done to the point of being worthless or even harmful.

    There’s also a problem in that genuine biological studies get reported on really poorly by the mainstream media. I co-authored a paper showing that in 3 tests of cognitive function, spread over three days, people with long covid did not preform worse than the general population. However, if you made them do these three tests in a row, people with long covid would preform markedly worse than healthy controls, so they have a problem with cognitive endurance.

    A handful of news outlets reported on this, and oftenso the news articles did not include the second part of the study, just saying “people with long covid do not have cognitive dysfunction” or “brain fog debunked”. There’s really a push from the right to delegitimise long covid and it is hurting scientific integrity hard.