Depends how far into vfio you want to go. I run a proxmox VM to stream games from my server to any tv in the house. You can also set it up on your main (and I do, but I like to tinker a lot so having back ups and flexibility is nice) with only one gpu as long as you have some way to launch your computer (either auto boot or through browser).

In terms of performance, there’s generally barely a noticeable difference between bare metal and vm.