I’ve seen people talk about actors and artists that had a terrible time.
My own would be Anne Rice. She wrote Interview with the Vampire after her young daughter died of Leukemia. Then her husband suddenly died of a brain hemorrhage. I suspect her Christian, anti-fanfic phase was a result of mental illness and manipulation from the publishers, although I don’t think she ever apologized.
She couldn’t reconcile being a devout Catholic with her son’s gayness, so she left the Church again. At the end of her life, she had Last Rites, according to Raymond Arroyo, who was a good friend of hers.